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KMID : 0371019980310030424
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Journal of Preventive Medicine and Public Health
1998 Volume.31 No. 3 p.424 ~ p.439
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A Study on Urinary Cadmium Concentration and Renal Indices of Inhabitant in an Abandoned Mine Area
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Park Jung-Duck
Park Chan-Byung
Choi Byung-Sun
Kang Eun-Yong
Hong Yeon-Pyo
Chang Im-Won
Chun Byung-Yeol
Yeh Min-Hae
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Abstract
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Urinary cadmium is used as a sensitive indicator for internal Cd dose, and increased excretion of N-acetyl-β-D-glucosaminidase(NAG), β₂-microglobulin(MG) and total protein are useful indices for renal dysfunction by chronic exposure to Cd. The target group was 184 inhabitant(82 men and 102 women) in an abandoned mine area known as exposure to low level Cd. The control group was took 160 individuals(64 men and 96 women) in Cd not-exposed area.
Urinary Cd concentration was significantly higher in the target group than the control. The geometric mean of urinary Cd for male was 2.56㎍/ℓ, 2.80㎍/g creatinine and 2.50㎍/S.G. in the target group and 1.19㎍/ℓ, 1.36㎍/g creatinine and 1.17㎍/S.G. in the control. For female 2.69㎍/ℓ, 3.94㎍/g creatinine and 2.63㎍/S.G. in the target group and 1.27㎍/ℓ, 1.97㎍/g creatinine and 1.25㎍/S.G. in the control, respectively. In addition, urinary Cd of the target group had affected by the period of residence and dietary habit for the rice and the vegetables from the target area. These findings suggest the chronic exposure to Cd of the target population.
Mean excretion of urinary NAG, β₂-MG and total protein were not significant between two groups. In the target group, urinary NAG activity and total protein were significantly correlated with urinary Cd, but β₂-MG was not related. Urinary excretion of NAG, β₂-MG and total protein were significantly increased in 10 than in <2 of urinary Cd level. In 2∼10 group of urinary Cd level, the excretion of NAG significantly increased while not showed for β₂-MG. In present study, urinary excretion of NAG was relatively sensitive than β₂-MG in chronic exposure population to low level Cd.
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KEYWORD
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urinary cadmium, N-acetyl-β-D-glucosaminidase, β₂-microglobulin
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